Griffin attended Maynard Evans High School in Orlando, Florida before transferring to Boone High School for his senior year after being cut multiple times from the basketball team at Evans. At Boone, he met head coach and former LSU guard Willie Anderson, who recognized Griffin’s freakish athleticism and unrelenting hunger for greatness. Anderson was the first one to give Griffin a chance, and he didn’t disappoint.
Following a solid first year of organized basketball, Griffin went on to play for Hiwassee Community College in Tennessee, where he averaged 16 points, six rebounds and two blocks per game in 2008–09. But when the small junior college lost its accreditation in 2009, Griffin was forced to move on. He transferred to Garden City Community College in Kansas, and in 2009–10, he played 32 games, averaging 8.1 points, 6.5 rebounds, and 1.6 blocks per game.
In 2010, he transferred to Campbell University. In his junior season, he scored in double figures 20 times, had five double-digit rebounding nights and set a school single-season Division I era (since 1977–78) record with 61 blocked shots. In 29 games (22 starts), he averaged 13.2 points, 6.9 rebounds, 1.0 assists, 1.7 steals and 2.1 blocks in 28.1 minutes per game.
In his senior season, he was named to the 2012 All-Big South Conference first team. In his two-year career at Campbell, he finished with the school’s highest career field goal percentage (.559) and ranks third on the school’s all-time blocks list with 134 rejections. In 31 games, he averaged 15.7 points, 8.6 rebounds, 1.5 assists and 2.4 blocks in 30.3 minutes per game.